Succinyl coenzyme A synthetase - Wikipedia
Succinyl coenzyme A synthetase (SCS, also known as succinyl-CoA synthetase or succinate thiokinase or succinate-CoA ligase) is an enzyme that catalyzes the reversible reaction of succinyl-CoA to succinate. [3]
Succinyl-CoA - Wikipedia
Succinyl-coenzyme A, abbreviated as succinyl-CoA (/ ˌsʌksɪnəlˌkoʊˈeɪ /) or SucCoA, is a thioester of succinic acid and coenzyme A. It is an important intermediate in the citric acid cycle, where it is synthesized from α-ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.
Succinyl-CoA Synthetase is a Phosphate Target for the Activation …
Succinyl-CoA synthetase (SCS) is the only mitochondrial enzyme capable of ATP production via substrate level phosphorylation in the absence of oxygen, but it also plays a key role in the citric acid cycle, ketone metabolism and heme synthesis.
Succinyl Coenzyme A Synthetase - an overview - ScienceDirect
Succinyl-CoA thiokinase (EC 6.2.1.5 (ATP-dependent form) and EC 6.2.1.4 (GTP-dependent form); also known as succinyl coenzyme A synthetase, or succinate thiokinase) is an essential enzyme in tricarboxylic acid cycle catalysing the reversible …
Succinyl-CoA - an overview | ScienceDirect Topics
Succinyl-CoA thiokinase (EC 6.2.1.5 (ATP-dependent form) and EC 6.2.1.4 (GTP-dependent form); also known as succinyl coenzyme A synthetase, or succinate thiokinase) is an essential enzyme in tricarboxylic acid cycle catalysing the reversible …
Identification of the kinetic mechanism of succinyl-CoA synthetase …
The kinetic mechanism of SCS [succinyl-CoA (coenzyme A) synthetase], which participates in the TCA (tricarboxylic acid) cycle, ketone body metabolism and haem biosynthesis, has not been fully characterized.
Succinyl-CoA Synthetase Dysfunction as a Mechanism of …
SCS catalyzes the interconversion of succinyl-CoA to succinate, coupled to substrate-level phosphorylation of either ADP or GDP, within the TCA cycle. SCS-deficient encephalomyopathy typically presents in infancy and early childhood, with many patients succumbing to the disease during childhood.
Structure of GTP-specific succinyl-CoA synthetase in complex with CoA
2015年8月8日 · Succinyl-CoA synthetase (SCS; also known as succinate-CoA ligase) is responsible for breaking down succinyl-CoA to succinate and CoA, accompanied by the phosphorylation of NDP (ADP or GDP) to NTP (ATP or GTP) in the citric acid cycle (Sanadi et al., 1956 ): succinyl-CoA + NDP + P i ⇌ succinate + CoA + NTP. The reaction catalyzed by SCS is ...
18. Succinyl-Coa Synthetase - ScienceDirect
1974年1月1日 · This chapter discusses the molecular and catalytic properties of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction, which may be considered to be the interconversion of two kinds of high energy bonds: thiolester and phosphate anhydride.
Succinyl coenzyme A synthetase - WikiMili
Succinyl coenzyme A synthetase (SCS, also known as succinyl-CoA synthetase or succinate thiokinase or succinate-CoA ligase) is an enzyme that catalyzes the reversible reaction of succinyl-CoA to succinate.