Syncytium - Wikipedia
A syncytium (/ sɪnˈsɪʃiəm /; pl.: syncytia; from Greek: σύν syn "together" and κύτος kytos "box, i.e. cell") or symplasm is a multinucleate cell that can result from multiple cell fusions of uninuclear cells (i.e., cells with a single nucleus), in contrast to a coenocyte, which can result from multiple nuclear divisions without accompanying cyto...
The role of syncytia during viral infections - PubMed
2021年9月21日 · RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together. We use a mathematical model to study how different assumptions about the viral production and lifespan of syncytia change the resulting infection time course.
Syncytia formation during SARS-CoV-2 lung infection: a ... - Nature
2021年5月12日 · Syncytia are evolutionarily conserved cellular structures form by the multiple cell fusions of uninuclear cells. In mammals, the best example of physiological syncytia is muscle fibers, which...
Syncytia formation during SARS-CoV-2 lung infection: a …
Syncytia are evolutionarily conserved cellular structures form by the multiple cell fusions of uninuclear cells. In mammals, the best example of physiological syncytia is muscle fibers, which contain thousands of fused muscle cells to allows their rapid coordinated contraction .
Syncytia formation by SARS-CoV-2-infected cells - PubMed
2020年12月1日 · Here, we show that SARS-CoV-2-infected cells express the Spike protein (S) at their surface and fuse with ACE2-positive neighboring cells. Expression of S without any other viral proteins triggers syncytia formation.
The Mechanism and Consequences of SARS-CoV-2 Spike …
Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the viral spike (S) protein on the surface of an infected cell interacts with receptors on neighboring cells. Syncytia may potentially contribute to pathology by facilitating viral dissemination, cytopathicity, immune evasion, and inflammatory response.
Syncytia formation by SARS‐CoV‐2‐infected cells - PMC
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we show ...
The role of syncytia during viral infections - ScienceDirect
2021年9月21日 · Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract. RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together.
Syncytia: Origin, Structure, and Functions | SpringerLink
This book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis and organogenesis. It also reviews pathogen-induced syncytia and the role of syncytial cells in cancer development.
SARS-CoV-2 spike protein dictates syncytium-mediated …
2021年4月20日 · Here, we demonstrated that the syncytia, resulted from SARS-CoV-2 infection, could target the infiltrated lymphocytes for internalization and CIC mediated death, contributing to lymphopenia...