Toll-like receptor - Wikipedia
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages …
Toll 样受体信号转导 | Cell Signaling Technology
Toll 样受体 (TLRs) 可识别不同的病原体相关分子模式，并在先天性免疫应答中扮演着不可或缺的角色。它们是抵御病原体入侵的第一道防线，在炎症、免疫细胞调控、存活和增殖方面发挥着 …
Toll-Like Receptor Signaling Pathways - Frontiers
2014年9月24日 · Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes...
Toll-like receptor signaling pathway - Homo sapiens (human)
Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages …
Toll-like Receptors and the Control of Immunity - Cell Press
Herein, we describe the mechanisms and consequences of TLR-mediated signal transduction with a focus on themes identified in the TLR pathways that also explain the operation of other …
Toll-like receptor signalling | Nature Reviews Immunology
2004年7月1日 · Stimulation of Toll-like receptor 4 (TLR4) facilitates the activation of two pathways: the MyD88 (myeloid differentiation primary-response protein 88)-dependent and …
Toll-like receptors activation, signaling, and targeting: an …
2019年12月12日 · Toll-like receptors (TLRs) are an important family of receptors that constitute the first line of defense system against microbes. They can recognize both invading pathogens …
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and …
Toll-Like Receptor Signaling Pathways | Science - AAAS
2003年6月6日 · Members of the Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharide and viral double-stranded RNA, and activate …
Toll-like receptors and innate immunity - Nature
2001年11月1日 · Drosophila has two main pathways of microbial recognition. The Toll pathway is involved in recognition of fungal and Gram-positive bacterial pathogens.