Molecular principles of metastasis: a hallmark of cancer ...
2020年3月12日 · Overview of the metastatic cascade: The five key steps of metastasis include invasion, intravasation, circulation, extravasation, and colonization.
How Cancer Spreads (Metastasis) - CancerQuest
Metastasis is the process by which cancer cells spread to distant locations in the body. The majority of death associated with cancer is due to the metastasis of the original tumor cells. Metastasizing cancer cells must secrete a mixture of digestive enzymes in order to …
Steps in metastasis: an updated review - PubMed
2021年1月4日 · Initiation of metastasis relies on the tumor cell cross-talking with stromal cells and taking an epithelial-mesenchymal transition (EMT) in single cells, and a hybrid EMT in collective migratory cells.
Steps in metastasis: an updated review | Medical Oncology
2021年1月4日 · The steps in metastasis are as followings: escape of cancer cells from primary tumor, intravasation, survival maintenance, extravasation (secondary site seeding) and outgrowth (colonization) [5,6,7,8,9].
Defining the Hallmarks of Metastasis - PMC
Metastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well as interactions between cancer cells and multiple microenvironments. The outcome is the development of a nearby or distant discontiguous secondary mass.
Mechanisms of cancer metastasis - ScienceDirect
2022年12月1日 · This review describes our current understanding of cancer metastasis, detailing what is known about each step of the metastatic process. Key future directions are presented, and the need for innovative therapeutic approaches that combine therapies personalized to each patient’s mutation and/or immune profile are also discussed.
The overall process of metastasis: From initiation to a new ...
2022年7月1日 · In this article, we will focus on each step of tumor metastasis, describe the specific process and research progress, explore treatments and poor personal habits related to metastasis, and provide new insights.