Nifedipine is prepared by means of the Hantzsch pyridine synthesis. Suggest a synthesis of Nifedipine which utilizes an aldehyde as one of the starting materials. Also, outline the general reaction mechanism of the Hantzsch pyridine synthesis.

SOLVED:Propose curly arrow mechanism for the reaction shown below (part of a 'Kronke pyridine synthesis"). Hint: use of 1SN-labelled NHAOAc resulted in ISN-labelled product (20)NHAOAc AcOH 120 'CSPhSPh

PPT - The Synthesis of Pyridine; Over a Century of Research PowerPoint Presentation - ID:3663825

SOLVED: Consider the reaction between an alcohol and tosyl chloride, followed by a nucleophile. Write the condensed formula of the expected main organic product:TsCl pyridine CH3CH2CH2OH → CH3CH2CH2OTs pyridine

SOLVED:Although alcohol V gives a single alkene W when treated with POCl3 and pyridine, three isomeric alkenes (X-Z) are formed on dehydration with H2SO4. Draw a stepwise mechanism for each reaction and explain why the difference occurs.

SOLVED: Reaction of an alcohol with thionyl chloride in the presence of a tertiary amine (e.g., pyridine) affords replacement of the OH group by Cl with inversion of configurnation (Section 11.9 ). However, if the amine is omitted, the result is usually replacement with retention of configuration. The same chlorosulfite intermediate is involved in both cases. Suggest a mechanism by which this intermediate can give the chlorinated product without inversion. | Numerade

SOLVED: Provide the major product(s) that you would obtain in the following reactions:CHsCHzOH pyridineSOClzOHCHgO CHaNHzNHz

The relative rates of the reactions of 2−,3−, and 4 -chloropyri... | Filo

The main product of the following reaction is: C6H5CH2CH(OH)CH(CH3)2 conc.H2SO4