I usually feel this numbness in my toes upon waking up. Toes can become numb or tingly when the nerves in your toes get mixed signals. Nerves are messengers in the body that have two jobs. First, they deliver signals from the brain to the other parts of the body. Second, they pass information from the rest of the body (like your toes) back to the brain. Peripheral neuropathy occurs when this communication between nerves doesn't work properly. The toes are particularly sensitive to peripheral neu